Group publications

 

Publikationer rss feed

2017
 

Comparative degradomics of porcine and human wound exudates unravels biomarker candidates for assessment of wound healing progression in trauma patients

Sabino, Fabio Mira Rocha ; Egli, Fabian E ; Savickas, Simonas ; Holstein, Jörg ; Kaspar, Daniela ; Rollmann, Mika ; Kizhakkedathu, Jayachandran N ; Pohlemann, Tim ; Smola, Hans ; auf dem Keller, Ulrich
in: Journal of Investigative Dermatology (ISSN: 0022-202X), vol: 138, issue: 2, pages: 413-422, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.jid.2017.08.032

 

Body Fluid Degradomics and Characterization of Basic N-Terminome

Sabino, Fabio Mira Rocha ; Hermes, O. ; auf dem Keller, Ulrich
part of: Methods in Enzymology, pages: 177-199, 2017, Elsevier Academic Press Inc,

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/bs.mie.2016.09.018

 

Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration

Bachofner, Marc ; Speicher, Tobias ; Bogorad, Roman L. ; Muzumdar, Sukalp ; Derrer, Carina P. ; Hurlimann, Fabrizio ; Böhm, Friederike ; Nanni, Paolo ; Kockmann, Tobias ; Kachaylo, Ekaterina ; Meyer, Michael ; Padrissa-Altés, Susagna ; Graf, Rolf ; Anderson, Daniel G. ; Koteliansky, Victor ; auf dem Keller, Ulrich ; Werner, Sabine
in: Developmental Cell (ISSN: 1534-5807), vol: 42, issue: 6, pages: 616-625, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.devcel.2017.07.025

 

Multidimensional analysis of protease substrates and their cellular origins in mixed secretomes from multiple cell types

Schlage, Pascal ; auf dem Keller, Ulrich
part of: Protein Terminal Profiling (ISBN: 978-1-4939-6849-7), pages: 91-104, 2017, Humana Press Inc.,

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1007/978-1-4939-6850-3_7

 

Time-resolved analysis of matrix metalloproteinase substrates in complex samples

Schlage, Pascal ; Egli, Fabian E. ; auf dem Keller, Ulrich
part of: Matrix Metalloproteases (ISBN: 978-1-4939-6861-9), pages: 185-198, 2017, Humana Press Inc.,

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1007/978-1-4939-6863-3_9

 

Targeted degradomics in protein terminomics and protease substrate discovery

Savickas, Simonas ; auf dem Keller, Ulrich
in: Biological Chemistry (ISSN: 1431-6730), vol: 399, issue: 1, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1515/hsz-2017-0187

2016
 

Autocrine and paracrine regulation of keratinocyte proliferation through a novel nrf2-il-36γ pathway

Kurinna, Svitlana ; Muzumdar, Sukalp ; Köhler, Ulrike Anne ; Kockmann, Tobias ; auf dem Keller, Ulrich ; Schäfer, Matthias ; Werner, Sabine
in: Journal of Immunology (ISSN: 0022-1767), vol: 196, issue: 11, pages: 4663-4670, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.4049/jimmunol.1501447

 

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors

Prudova, Anna ; Gocheva, Vasilena ; auf dem Keller, Ulrich ; Eckhard, Ulrich ; Olson, Oakley C. ; Akkari, Leila ; Butler, Georgina S. ; Fortelny, Nikolaus ; Lange, Philipp F. ; Mark, Jennifer C. ; Joyce, Johanna A. ; Overall, Christopher M.
in: Cell Reports (ISSN: 2211-1247), vol: 16, issue: 6, pages: 1762-1773, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1016/j.celrep.2016.06.086

2015
 

MMPs: From Genomics to Degradomics

Grünwald, Barbara ; Schlage, Pascal ; Krüger, Achim ; auf dem Keller, Ulrich
part of: Matrix Metalloproteinase Biology (ISBN: 9781118772324), pages: 153-181, 2017, Wiley,

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1002/9781118772287.ch9

 

In vivo assessment of protease dynamics in cutaneous wound healing by degradomics analysis of porcine wound exudates

Sabino, Fabio Mira Rocha ; Hermes, Olivia ; Egli, Fabian E. ; Kockmann, Tobias ; Schlage, Pascal ; Croizat, Pierre ; Kizhakkedathu, Jayachandran N. ; Smola, Hans ; auf dem Keller, Ulrich
in: Molecular and Cellular Proteomics (ISSN: 1535-9476), vol: 14, issue: 2, pages: 354-370, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1074/mcp.M114.043414

 

Proteomic approaches to uncover MMP function

Schlage, Pascal ; auf dem Keller, Ulrich
in: Matrix Biology (ISSN: 0945-053X), vol: 44-46, pages: 232-238, 2015

Type: Review (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1016/j.matbio.2015.01.003

 

Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes

Sollberger, Gabriel ; Strittmatter, Gerhard E. ; Grossi, Serena ; Garstkiewicz, Martha ; auf dem Keller, Ulrich ; French, Lars E. ; Beer, Hans Dietmar
in: Journal of Investigative Dermatology (ISSN: 0022-202X), vol: 135, issue: 5, pages: 1395-1404, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1038/jid.2014.551

 

Monitoring matrix metalloproteinase activity at the epidermal-dermal interface by SILAC-iTRAQ-TAILS

Schlage, Pascal ; Kockmann, Tobias ; Kizhakkedathu, Jayachandran N. ; auf dem Keller, Ulrich
in: Proteomics (ISSN: 1615-9853), vol: 15, issue: 14, pages: 2491-2502, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1002/pmic.201400627

 

Matrix metalloproteinase 10 degradomics in keratinocytes and epidermal tissue identifies bioactive substrates with pleiotropic functions

Schlage, Pascal ; Kockmann, Tobias ; Sabino, Fabio Mira Rocha ; Kizhakkedathu, Jayachandran N. ; auf dem Keller, Ulrich
in: Molecular and Cellular Proteomics (ISSN: 1535-9476), vol: 14, issue: 12, pages: 3234-3246, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1074/mcp.M115.053520

 

Identification of protease substrates in complex proteomes by iTRAQ-TAILS on a thermo Q exactive instrument

Kockmann, Tobias ; Carte, Nathalie ; Melkko, Samu ; auf dem Keller, Ulrich
in: Neuromethods (ISSN: 0893-2336), vol: 114, pages: 187-207, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1007/7657_2015_92

 

Matrix metalloproteinases in impaired wound healing

Sabino, Fabio ; auf dem Keller, Ulrich
in: Metalloproteinases In Medicine (ISSN: 2324-2027), vol: 2, pages: 1-8, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.2147/MNM.S68420

 

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

Eckhard, Ulrich ; Huesgen, Pitter F. ; Schilling, Oliver ; Bellac, Caroline L. ; Butler, Georgina S. ; Cox, Jennifer H. ; Dufour, Antoine ; Goebeler, Verena ; Kappelhoff, Reinhild ; auf dem Keller, Ulrich ; Klein, Theo ; Lange, Philipp F. ; Marino, Giada ; Morrison, Charlotte J. ; Prudova, Anna ; Rodríguez, David ; Starr, Amanda E. ; Wang, Yili ; Overall, Christopher M.
in: Matrix Biology (ISSN: 0945-053X), vol: 49, pages: 37-60, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1016/j.matbio.2015.09.003

2014
 

Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome

Schlage, Pascal ; Egli, Fabian E. ; Nanni, Paolo ; Wang, Lauren W. ; Kizhakkedathu, Jayachandran N. ; Apte, Suneel S. ; auf dem Keller, Ulrich
in: Molecular and Cellular Proteomics (ISSN: 1535-9476), vol: 13, issue: 2, pages: 580-593, 2014

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: http://dx.doi.org/10.1074/mcp.M113.035139

 

Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis

Bellac, Caroline L. ; Dufour, Antoine ; Krisinger, Michael J. ; Loonchanta, Anantasak ; Starr, Amanda E. ; auf dem Keller, Ulrich ; Lange, Philipp F. ; Goebeler, Verena ; Kappelhoff, Reinhild ; Butler, Georgina S. ; Burtnick, Leslie D. ; Conway, Edward M. ; Roberts, Clive R. ; Overall, Christopher M.
in: Cell Reports (ISSN: 2211-1247), vol: 9, issue: 2, pages: 618-632, 2014

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: http://dx.doi.org/10.1016/j.celrep.2014.09.006

2013
 

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

Jefferson, Tamara ; auf dem Keller, Ulrich ; Bellac, Caroline ; Metz, Verena V. ; Broder, Claudia ; Hedrich, Jana ; Ohler, Anke ; Maier, Wladislaw ; Magdolen, Viktor ; Sterchi, Erwin ; Bond, Judith S. ; Jayakumar, Arumugam ; Traupe, Heiko ; Chalaris, Athena ; Rose-John, Stefan ; Pietrzik, Claus U. ; Postina, Rolf ; Overall, Christopher M. ; Becker-Pauly, Christoph
in: Cellular and Molecular Life Sciences (ISSN: 1420-682X), vol: 70, issue: 2, pages: 309-333, 2013

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: http://dx.doi.org/10.1007/s00018-012-1106-2

2012
 

CLIPPER

auf dem Keller, Ulrich ; Overall, Christopher M.
in: Biological Chemistry (ISSN: 1431-6730), vol: 393, issue: 12, pages: 1477-1483, 2012

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2012     |    DOI: http://dx.doi.org/10.1515/hsz-2012-0269

 

Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening

Lieder, Franziska ; Reisen, Felix ; Geppert, Tim ; Sollberger, Gabriel ; Beer, Hans Dietmar ; auf dem Keller, Ulrich ; Schäfer, Matthias ; Detmar, Michael ; Schneider, Gisbert ; Werner, Sabine
in: Journal of Biological Chemistry (ISSN: 0021-9258), vol: 287, issue: 39, pages: 33001-33013, 2012

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2012     |    DOI: http://dx.doi.org/10.1074/jbc.M112.383430

2011
 

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry

Schilling, Oliver ; Huesgen, Pitter F. ; Barre, Olivier ; auf dem Keller, Ulrich ; Overall, Christopher M.
in: Nature Protocols (Online) (ISSN: 1750-2799), vol: 6, issue: 1, pages: 111-120, 2011

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: http://dx.doi.org/10.1038/nprot.2010.178

 

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Lou, Yuanmei ; McDonald, Paul C. ; Oloumi, Arusha ; Chia, Stephen ; Ostlund, Christina ; Ahmadi, Ardalan ; Kyle, Alastair ; auf dem Keller, Ulrich ; Leung, Samuel ; Huntsman, David ; Clarke, Blaise ; Sutherland, Brent W. ; Waterhouse, Dawn ; Bally, Marcel ; Roskelley, Calvin ; Overall, Christopher M. ; Minchinton, Andrew ; Pacchiano, Fabio ; Carta, Fabrizio ; Scozzafava, Andrea ; Touisni, Nadia ; Winum, Jean-Yves ; Supuran, Claudiu T. ; Dedhar, Shoukat
in: Cancer Research (ISSN: 0008-5472), vol: 71, issue: 9, pages: 3364-3376, 2011

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-4261

 

Metalloprotease meprin β generates nontoxic N-terminal amyloid precursor protein fragments in vivo

Jefferson, Tamara ; Čaušević, Mirsada ; auf dem Keller, Ulrich ; Schilling, Oliver ; Isbert, Simone ; Geyer, Rebecca ; Maier, Wladislaw ; Tschickardt, Sabrina ; Jumpertz, Thorsten ; Weggen, Sascha ; Bond, Judith S. ; Overall, Christopher M. ; Pietrzik, Claus U. ; Becker-Pauly, Christoph
in: Journal of Biological Chemistry (ISSN: 0021-9258), vol: 286, issue: 31, pages: 27741-27750, 2011

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: http://dx.doi.org/10.1074/jbc.M111.252718