Group publications

 

Publikationer rss feed

2018
 

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, Inge ; Vesth, Tammi Camilla ; Frisvad, Jens Christian ; Rasmussen, Jane Lind Nybo ; Theobald, Sebastian ; Kuo, Alan ; Bowyer, Paul ; Matsuda, Yudai ; Mondo, Stephen ; Lyhne, Ellen Kirstine ; Kogle, Martin Engelhard ; Clum, Alicia ; Lipzen, Anna ; Salamov, Asaf ; Ngan, Chew Yee ; Daum, Chris ; Chiniquy, Jennifer ; Barry, Kerrie ; LaButti, Kurt ; Haridas, Sajeet ; Simmons, Blake A. ; Magnuson, Jon K. ; Mortensen, Uffe Hasbro ; Larsen, Thomas Ostenfeld ; Grigoriev, Igor V. ; Baker, Scott E. ; Andersen, Mikael Rørdam
in journal: Proceedings of the National Academy of Sciences of the United States of America (ISSN: 0027-8424) (DOI: http://dx.doi.org/10.1073/pnas.1715954115), vol: 115, issue: 4, pages: E753-E761, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1073/pnas.1715954115

 

Efficient Oligo nucleotide mediated CRISPR-Cas9 Gene Editing in Aspergilli

Nødvig, Christina Spuur ; Hoof, Jakob Blæsbjerg ; Kogle, Martin Engelhard ; Jarczynska, Zofia Dorota ; Lehmbeck, Jan ; Klitgaard, Dorte K ; Mortensen, Uffe Hasbro
in journal: Fungal Genetics and Biology (ISSN: 1087-1845) (DOI: http://dx.doi.org/10.1016/j.fgb.2018.01.004), 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.fgb.2018.01.004

2017
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Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9

Nielsen, Maria Lund ; Petersen, Thomas Isbrandt ; Rasmussen, Kasper Bøwig ; Thrane, Ulf ; Hoof, Jakob Blæsbjerg ; Larsen, Thomas Ostenfeld ; Mortensen, Uffe Hasbro
in journal: P L o S One (ISSN: 1932-6203) (DOI: http://dx.doi.org/10.1371/journal.pone.0169712), vol: 12, issue: 1, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1371/journal.pone.0169712

 

Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing

Weber, Jakob ; Valiante, Vito ; Nødvig, Christina Spuur ; Mattern, Derek J. ; Slotkowski, Rebecca A. ; Mortensen, Uffe Hasbro ; Brakhage, Axel A.
in journal: A C S Synthetic Biology (ISSN: 2161-5063) (DOI: http://dx.doi.org/10.1021/acssynbio.6b00203), vol: 6, issue: 1, pages: 62–68, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1021/acssynbio.6b00203

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CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast

Strucko, Tomas ; Buron, Line Due ; Jarczynska, Zofia Dorota ; Nødvig, Christina Spuur ; Mølgaard, Louise ; Halkier, Barbara Ann ; Mortensen, Uffe Hasbro
in journal: Scientific Reports (ISSN: 2045-2322) (DOI: http://dx.doi.org/10.1038/srep41431), vol: 7, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1038/srep41431

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Genome Sequence of Talaromyces atroroseus, Which Produces Red Colorants for the Food Industry

Thrane, Ulf ; Rasmussen, Kasper Bøwig ; Petersen, Bent ; Rasmussen, Simon ; Sicheritz-Pontén, Thomas ; Mortensen, Uffe Hasbro
in journal: Genome Announcements (ISSN: 2169-8287) (DOI: http://dx.doi.org/10.1128/genomeA.01736-16), vol: 5, issue: 9, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1128/genomeA.01736-16

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SWITCH: a dynamic CRISPR tool for genome engineering and metabolic pathway control for cell factory construction in Saccharomyces cerevisiae

Garcia Vanegas, Katherina ; Lehka, Beata Joanna ; Mortensen, Uffe Hasbro
in journal: Microbial Cell Factories (ISSN: 1475-2859) (DOI: http://dx.doi.org/10.1186/s12934-017-0632-x), vol: 16, issue: 25, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1186/s12934-017-0632-x

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Erratum to: SWITCH: a dynamic CRISPR tool for genome engineering and metabolic pathway control for cell factory construction in Saccharomyces cerevisiae

Garcia Vanegas, Katherina ; Lehka, Beata Joanna ; Mortensen, Uffe Hasbro
in journal: Microbial Cell Factories (ISSN: 1475-2859) (DOI: http://dx.doi.org/10.1186/s12934-017-0668-y), vol: 16, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1186/s12934-017-0668-y

 

Editorial: 3Rs tightly intertwined to maintain genome stability

Lisby, Michael (Editor) ; Mortensen, Uffe Hasbro (Editor)
in journal: Fems Yeast Research (ISSN: 1567-1356) (DOI: http://dx.doi.org/10.1093/femsyr/fox003), vol: 17, issue: 1, 2017

Type: Editorial (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1093/femsyr/fox003

 

Effects of Dissolved Oxygen Concentration and Iron Addition on Immediate-early Gene Expression of Magnetospirillum gryphiswaldense MSR-1

Zhuang, Shiwen ; Anyaogu, Diana Chinyere ; Kasama, Takeshi ; Workman, Mhairi ; Mortensen, Uffe Hasbro ; Hobley, Timothy John
in journal: Fems Microbiology Letters (ISSN: 0378-1097) (DOI: http://dx.doi.org/10.1093/femsle/fnx079), vol: 364, issue: 11, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1093/femsle/fnx079

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Gene expression plasticity across hosts of an invasive scale insect species

Christodoulides, Nicholas ; Van Dam, Alex ; Peterson, Daniel A. ; Frandsen, Rasmus John Normand ; Mortensen, Uffe Hasbro ; Petersen, Bent ; Rasmussen, Simon ; Normark, Benjamin B. ; Hardy, Nate B.
in journal: P L o S One (ISSN: 1932-6203) (DOI: http://dx.doi.org/10.1371/journal. pone.0176956), vol: 12, issue: 5, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1371/journal. pone.0176956

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Metabolic engineering of yeast for fermentative production of flavonoids

Rodriguez Prado, Edith Angelica ; Strucko, Tomas ; Stahlhut, Steen Gustav ; Kristensen, Mette ; Svenssen, Daniel Killerup ; Förster, Jochen ; Nielsen, Jens ; Borodina, Irina
in journal: Bioresource Technology (ISSN: 0960-8524) (DOI: http://dx.doi.org/10.1016/j.biortech.2017.06.043), vol: 245, issue: Part B, pages: 1645-1654, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.biortech.2017.06.043

 

Synthesis of C-Glucosylated Octaketide Anthraquinones in Nicotiana benthamiana by Using a Multispecies-Based Biosynthetic Pathway

Andersen-Ranberg, Johan ; Kongstad, Kenneth Thermann ; Nafisi, Majse ; Stærk, Dan ; Okkels, Finn Thyge ; Mortensen, Uffe Hasbro ; Møller, Birger Lindberg ; Frandsen, Rasmus John Normand ; Kannangara, Rubini
in journal: Chembiochem (ISSN: 1439-4227) (DOI: http://dx.doi.org/10.1002/cbic.201700331), vol: 18, issue: 19, pages: 1893-1897, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1002/cbic.201700331

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Physiological characterization of secondary metabolite producing Penicillium cell factories

Grijseels, Sietske ; Nielsen, Jens ; Larsen, Thomas Ostenfeld ; Frisvad, Jens Christian ; Nielsen, Kristian Fog ; Frandsen, Rasmus John Normand ; Workman, Mhairi
in journal: Fungal Biology and Biotechnology (ISSN: 2054-3085) (DOI: http://dx.doi.org/10.1186/s40694-017-0036-z), vol: 4, issue: 8, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1186/s40694-017-0036-z

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Microbial platform for production of aromatic compounds

Skovbjerg, Christine Alexandra Egaa ; Olsen, Kresten Jon Kromphardt ; Larsen, Thomas Ostenfeld ; Frandsen, Rasmus John Normand
Presented at:
No title found for this event

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2017

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Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Kannangara, Rubini ; Siukstaite, Lina ; Borch-Jensen, Jonas ; Madsen, Bjorn ; Kongstad, Kenneth T. ; Stærk, Dan ; Bennedsen, Mads ; Okkels, Finn T. ; Rasmussen, Silas Anselm ; Larsen, Thomas Ostenfeld ; Frandsen, Rasmus John Normand ; Møller, Birger Lindberg
in journal: Nature Communications (ISSN: 2041-1723) (DOI: http://dx.doi.org/10.1038/s41467-017-02031-z), vol: 8, issue: 1, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1038/s41467-017-02031-z

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Genus level analysis of secondary metabolism reveals the origin of Aspergillus hybrid NRPS-PKS gene clusters

Theobald, Sebastian ; Vesth, Tammi Camilla ; Rasmussen, Jane Lind Nybo ; Kjærbølling, Inge ; Frisvad, Jens Christian ; Nielsen, Kristian Fog ; Larsen, Thomas Ostenfeld ; Grigoriev, Igor V. ; Salamov, Asaf ; Mortensen, Uffe Hasbro ; Baker, Scott E. ; Andersen, Mikael Rørdam
Presented at:
14th International Aspergillus Meeting, 2017, Pacific Grove

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2017

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Elucidating the biosynthetic pathway of the anticancer secondary metabolite calbistrin in Penicillium decumbens

Grijseels, Sietske ; Pohl, Carsten ; Wasil, Zahida ; Froslev Nielsen, Jens Christian ; Nygård, Yvonne ; Nielsen, Jens ; Frisvad, Jens Christian ; Nielsen, Kristian Fog ; Workman, Mhairi ; Larsen, Thomas Ostenfeld ; Driessen, Arnold J.M. ; Frandsen, Rasmus John Normand
Presented at:
29th Fungal Genetics Conference, 2017, Pacific Grove

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2017

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Functional reconstitution of the Trypacidin Gene Cluster in Aspergillus fumigatus by Advanced Gene Editing

Weber, J. ; Valiante, Vito ; Nødvig, Christina Spuur ; Mattern, Derek J. ; Slotkowski, Rebecca A. ; Mortensen, Uffe Hasbro ; Brakhage, Axel A.
Presented at:
29th Fungal Genetics Conference, 2017, Pacific Grove

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2017

2016
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Use of heterologous expressed polyketide synthase and small molecule foldases to make aromatic and cyclic compounds

Frandsen, Rasmus John Normand (Inventor) ; Mortensen, Uffe Hasbro (Inventor) ; Coumou, Hilde (Inventor) ; Kannangara, Rubini (Inventor) ; Madsen, Lars (Inventor) ; Nafisi, Majse (Inventor) ; Ranberg, Johan Andersen (Inventor) ; Kongstad, Kenneth Thermann (Inventor) ; T. Okkels, Finn (Inventor) ; Khorsand-Jamal, Paiman (Inventor) ; Stærk, Dan (Inventor)
Patent no.: WO2016198623, Date: 15-12-2016

Type: Patent

Status: Published     |    Year: 2016

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Quantification of oxidative stress phenotypes based on high-throughput growth profiling of protein kinase and phosphatase knockouts

Altıntaş, Ali ; Martini, Jacopo ; Mortensen, Uffe Hasbro ; Workman, Christopher
in journal: Fems Yeast Research (ISSN: 1567-1356) (DOI: http://dx.doi.org/10.1093/femsyr/fov101), vol: 16, issue: 1, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1093/femsyr/fov101

 

Heme metabolism in stress regulation and protein production: from Cinderella to a key player

Martinez Ruiz, José Luis ; Petranovic, D. ; Nielsen, Jens
in journal: Bioengineered (ISSN: 1949-1018) (DOI: http://dx.doi.org/10.1080/21655979.2015.1126016), vol: 7, issue: 2, pages: 112-115, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1080/21655979.2015.1126016