Group publications

2017 -

Folkvardsen DB, Norman A, Andersen ÅB, Rasmussen EM, Jelsbak L*, Lillebaek T* (2017) Genomic epidemiology of a major Mycobacterium tuberculosis outbreak: Retrospective cohort study in a low incidence setting using sparse time-series sampling. Journal of Infectious Diseases, 216(3):366-374. doi: 10.1093/infdis/jix298.

Amador CI, Sternberg C, and Jelsbak L (2017) Application of RNA-seq and bioimaging methods to study microbe-microbe interactions and their effects on biofilm and gene expression. Methods Mol Biol, In Press

Lauridsen RK, Sommer LM, Johansen HK, Rindzevicius T, Molin S, Jelsbak L, Engelsen SB, Boisen A (2017) SERS detection of the biomarker hydrogen cyanide from Pseudomonas aeruginosa cultures isolated from cystic fibrosis patients. Scientific Reports, 7:45264. doi: 10.1038/srep45264.

Bartell JA, Blazier AS, Yen P, Thøgersen JC, Jelsbak L, Goldberg JB, and Papin JA (2017) Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis. Nature Communication, 8:14631. doi: 10.1038/ncomms14631.

2016

Wigneswaran V, Nielsen KF, Sternberg C, Jensen PR, Folkesson A, and Jelsbak L (2016) Biofilm as a production platform for heterologous production of rhamnolipids by the non-pathogenic strain Pseudomonas putida KT2440. Microbial Cell Factories, 15(1):181

Jochumsen N, Marvig R, Damkiær S, Jensen RL, Paulander W, Molin S, Jelsbak L, and Folkesson A (2016) The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions. Nature Communication, 7:13002. doi: 10.1038/ncomms13002.

Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, Boya P CA, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJ, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AM, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BØ, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N (2016) Sharing and community curation of mass spectra by GNPS. Nature Biotechnology, 34(8):828-37. doi: 10.1038/nbt.3597.

Thrane SW, Taylor VL, Lund O, Lam JS and Jelsbak L (2016). Application of WGS data for OSA analysis and in silico serotyping of Pseudomonas aeruginosa isolates. Journal of Clinical Microbiology, 54(7):1782-8. doi: 10.1128/JCM.00349-16

Norman A, Ciofu O, Amador CI, Høiby N, and Jelsbak L (2016) Genome Sequence of Pseudomonas aeruginosa Strain DK1-NH57388A, a Stable Mucoid Cystic Fibrosis Isolate. Genome Announc. 4(1). pii: e00008-16. doi: 10.1128/genomeA.00008-16.

Michelsen CF, Khademi SM, Johansen HK, Ingmer H, Dorrestein PC, and Jelsbak L. (2016) Evolution of metabolic divergence in Pseudomonas aeruginosa during long-term infection facilitates a proto-cooperative interspecies interaction. ISME Journal, 10(6):1323-36. doi: 10.1038/ismej.2015.220

Lillebaek T, Norman A, Rasmussen EM, Marvig RL, Folkvardsen DB, Andersen AB, Jelsbak L (2016) Substantial molecular evolution and mutation rates in prolonged latent Mycobacterium tuberculosis infection in humans. International Journal of Medical Microbiology, pii: S1438-4221(16)30110-2. doi: 10.1016/j.ijmm.2016.05.017.

Wassermann T, Jørgensen KM, Ivanyshyn K, Bjarnsholt T, Khademi SM, Jelsbak L, Høiby N, and Ciofu O. (2016) The phenotypic evolution of P. aeruginosa populations changes in the presence of sub-inhibitory concentrations of ciprofloxacin. Microbiology, 162(5):865-75. doi: 10.1099/mic.0.000273.

Wigneswaran V, Amador CI, Jelsbak L, Sternberg C, and Jelsbak L (2016) Utilization and control of ecological interactions in polymicrobial infections and community-based microbial cell factories. F1000 Research, 5(F1000 Faculty Rev): 421. doi: 10.12688/f1000research.7876.1

Taylor VL, Hoage J, Thrane SW, Huszczynski SM, Jelsbak L, and Lam JS. (2016) A bacteriophage-acquired O-antigen polymerase (Wzyβ) from P. aeruginosa serotype O16 performs a varied mechanism compared to its cognate Wzyα. Frontiers in Microbiology, 7:393. doi: 10.3389/fmicb.2016.00393.

Vestergaard M, Paulander W, Marvig RL, Clasen J, Jochumsen N, Molin S, Jelsbak L, Ingmer H, and Folkesson A (2016) Antibiotic combination therapy selects for broad-spectrum multidrug resistance in Pseudomonas aeruginosa. International Journal of Antimicrobial Agents, 47(1):48-55. doi: 10.1016/j.ijantimicag.2015.09.014

2015

Thrane SW, Taylor VL, Freschi L, Kukavica-Ibrulj I, Boyle B, Laroche J, Pirnay JP, Lévesque RC, Lam JS, Jelsbak L (2015) The MDR serotype O12 Pseudomonas aeruginosa clone emerged through concomitant horizontal transfer of serotype antigen and antibiotic resistance genes. mBio, 6(5): e01396-15. doi: 10.1128/mBio.01396-15.

Ghoul M, West SA, Johansen HK, Molin S, Harrison O, Maiden M, Jelsbak L, Bruce JB, Griffin AS (2015) Bacteriocin-mediated competition in cystic fibrosis lung infections. Proc R Soc B. 282(1814). pii: 20150972.

Freschi L, Jeukens J, Kukavica-Ibrulj I, Boyle B, Dupont MJ, Laroche J, Larose S, Maaroufi H, Fothergill JL, Moore M, Winsor GL, Aaron SD, Barbeau J, Bell SC, Burns JL, Camara M, Cantin A, Charette SJ, Dewar K, Déziel É, Grimwood K, Hancock RE, Harrison JJ, Heeb S, Jelsbak L, Jia B, Kenna DT, Kidd TJ, Klockgether J, Lam JS, Lamont IL, Lewenza S, Loman N, Malouin F, Manos J, McArthur AG, McKeown J, Milot J, Naghra H, Nguyen D, Pereira SK, Perron GG, Pirnay JP, Rainey PB, Rousseau S, Santos PM, Stephenson A, Taylor V, Turton JF, Waglechner N, Williams P, Thrane SW, Wright GD, Brinkman FS, Tucker NP, Tümmler B, Winstanley C, Levesque RC (2015) Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Frontiers in Microbiology, 6:1036. doi: 10.3389/fmicb.2015.01036

Marvig RL, Sommer LM, Jelsbak L, Molin S, Johansen HK (2015) Evolutionary insight from whole-genome sequencing of Pseudomonas aeruginosa from cystic fibrosis patients. Future Microbiol. 10:599-611. doi: 10.2217/fmb.15.3.

2014

Michelsen CF, Christensen AM, Bojer MS, Høiby N, Ingmer H, Jelsbak L (2014) Staphylococcus aureus alters growth activity, autolysis and antibiotic tolerance in a human host adapted Pseudomonas aeruginosa lineage. Journal of Bacteriology, 196(22):3903-11

Markussen T, Marvig RL, Lozano MG, Aanæs K, Burleigh A, Høiby N, Johansen HK, Molin S, Jelsbak L (2014) Environmental heterogeneity drives within-host diversification and evolution of Pseudomonas aeruginosa. MBio, 5(5):e01592-14. doi: 10.1128/mBio.01592-14.

Marvig RL, Damkiær S, Khademi SM, Markussen TM, Molin S, Jelsbak L (2014). Within-host evolution of Pseudomonas aeruginosa reveals adaptation toward iron acquisition from hemoglobin. MBio. 5(3):e00966-14. doi:10.1128/mBio.00966-14.

2013

Thøgersen J, Mårup M, Damkiær S, Molin S, and Jelsbak L (2013). Achetypal analysis of diverse Pseudomonas aeruginosa transcriptomes reveals adaptation in cystic fibrosis airways. BMC Bioinformatics, 14(1):279

Marvig R, Johansen HK, Molin S, and Jelsbak L (2013). Genome analysis of a transmissible lineage of Pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators. PLOS Genetics. 9(9): e1003741. doi:10.1371/journal.pgen.1003741

Damkiær S, Yang L, Molin S, and Jelsbak L (2013). Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts. Proc Natl Acad Sci USA. 110(19):7766-71

Marvig R, Jochumsen N, Johansen H, Høiby N, Molin S, Sommer M, Jelsbak L, and Folkesson A (2013). Draft genome sequences of Pseudomonas aeruginosa B3 strains sampled from cystic fibrosis patient undergoing antibiotic chemotherapy. Genome Announc, 1(5) pii: e00804-13. 

Salomonsen CM, Themudo GE, Jelsbak L, Molin S, Høiby N, and Hammer AS (2013). Typing of Pseudomonas aeruginosa from hemorrhagic pneumonia in mink. Veterinary Microbiology 163(1-2):103-9.

2012

Folkesson A#, Jelsbak L#, Yang L, Johansen HK, Ciofu O, Høiby N and Molin S (2012). Adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients: an evolutionary perspective. Nature Reviews Microbiology. 10(12):841-51.

Rau MH, Marvig R, Ehrlich GD, Molin S, and Jelsbak L (2012). Deletion and acquisition of genomic content during early stage adaptation of Pseudomonas aeruginosa to a human host environment. Environmental Microbiology 14(8):2200-11.

Marvig R, Søndergaard M, Damkiær S, Høiby N, Johansen HK, Molin S, and Jelsbak L (2012). Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 56(8):4519-21.

Larsen M, Cosentino S, Rasmussen S, Friis C, Hasman H, Marvig R, Jelsbak L, Pontén T, Ussery DW, Aarestrup F, and Lund O (2012). Multilocus sequence typing of total genome sequenced bacteria. Journal of Clinical Microbiology. 50(4):1355-61.

Hansen SK, Rau MH, Johansen HK, Ciofu O, Jelsbak L, Yang L, Folkesson A, Jarmer HO, Aanæs K, von Buchwald C, Høiby N, Molin S (2012). Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection. ISME Journal. 6(1):31-45.

2011

Yang L, Rau MH, Yang L, Høiby N, Molin S, Jelsbak L (2011). Bacterial adaptation during chronic infection revealed by independent component analysis of transcriptomic data. BMC Microbiology. 11:184

Yang L#, Jelsbak, L#, Marvig RL, Damkiær S, Workman CT, Rau MH, Hansen SK, Folkesson A, Johansen HK, Ciofu, O, Høiby N, Sommer MO, and Molin S (2011). Evolutionary dynamics of bacteria in a human host environment. Proc Natl Acad Sci USA. 108(18):7481-6.

12. Yang L, Jelsbak L, and Molin S (2011). Microbial ecology and adaptation in cystic fibrosis airways. Environmental Microbiology. 13(7):1682-9

2010

Rau MH, Hansen SK, Johansen HK, Thomsen LE, Workman CT, Nielsen KF, Jelsbak L, Høiby N, Yang L, Molin S (2010). Early adaptive developments of Pseudomonas aeruginosa after the transition from life in the environment to persistent colonization in the airways of human cystic fibrosis hosts. Environmental Microbiology. 12(6):1643-58.

2008

Yang L, Haagensen JAJ, Jelsbak L, Johansen HK, Sternberg C, Høiby N, and Molin S (2008). In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections. Journal of Bacteriology. 190:2767-2776.

Kill K, Binnewies TT, Willenbrock H, Hansen SK, Yang L, Jelsbak L, Ussery DW, and Friis C (2008). Comparative genomics of Pseudomonas. In: B. Rehm (ed.), Pseudomonas: Model Organism, Pathogen, Cell Factory. Wiley-VCH. p1-24.

2007

Schneiker S, Perlova O, Kaiser O, Gerth K, Alici A, Altmeyer MO, Bartels D, Bekel T, Beyer S, Bode E, Bode HB, Bolten CJ, Choudhuri JV, Doss S, Elnakady YA, Frank B, Gaigalat L, Goesmann A, Groeger C, Gross F, Jelsbak L, Jelsbak L, Kalinowski J, Kegler C, Knauber T, Konietzny S, Kopp M, Krause L, Krug D, Linke B, Mahmud T, Martinez-Arias R, McHardy AC, Merai M, Meyer F, Mormann S, Muñoz-Dorado J, Perez J, Pradella S, Rachid S, Raddatz G, Rosenau F, Rückert C, Sasse F, Scharfe M, Schuster SC, Suen G, Treuner-Lange A, Velicer GJ, Vorhölter FJ, Weissman KJ, Welch RD, Wenzel SC, Whitworth DE, Wilhelm S, Wittmann C, Blöcker H, Pühler A, Müller R (2007). Complete sequence of the largest known bacterial genome from the myxobacterium Sorangium cellulosum. Nature Biotechnology. 25:1281-1289.

Jelsbak L, Johansen HK, Frost AL, Thøgersen R, Thomsen LE, Ciofu O, Yang L, Haagensen JAJ, Høiby N, and Molin S (2007). Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients. Infection and Immunity. 75: 2214-2224.

2005

Jelsbak L, Givskov M, and Kaiser D. (2005). Enhancer-binding proteins with a forkhead-associated domain and the sigma54 regulon in Myxococcus xanthus fruiting body development. Proc Natl Acad Sci USA. 102(8):3010-5.

2004

Jakobsen JS, Jelsbak L, Jelsbak L, Welch RD, Cummings C, Goldman B, Stark E, Slater S, and Kaiser D (2004). Sigma54 enhancer binding proteins and Myxococcus xanthus fruiting body development. Journal of acteriology. 186(13):4361-8.

2003

Jelsbak L and Søgaard-Andersen L (2003). Cell behavior and cell-cell communication during fruiting body morphogenesis in Myxococcus xanthus. J Microbiol Methods. 55(3):829-39.

Søgaard-Andersen L, Overgaard M, Lobedanz S, Ellehauge E, Jelsbak L, and Rasmussen AA (2003). Coupling gene expression and multicellular morphogenesis during fruiting body formation in Myxococcus xanthus. Molecular Microbiology. 48(1):1-8.

2002

 Jelsbak L and Søgaard-Andersen L (2002). Pattern formation by a cell surface-associated morphogen in Myxococcus xanthus. Proc Natl Acad Sci USA. 99(4):2032-7.

2000

Jelsbak L and Søgaard-Andersen L (2000). Pattern formation: fruiting body morphogenesis in Myxococcus xanthus. Current Opinion in Microbiology. 3(6):637-42.

1999

Jelsbak L and Søgaard-Andersen L (1999). The cell surface-associated intercellular C-signal induces behavioral changes in individual Myxococcus xanthus cells during fruiting body morphogenesis. Proc Natl Acad Sci USA. 96(9):5031-6.


Contact

Lars Jelsbak
Professor MSO
DTU Bioengineering
+45 45 25 61 29