Group publications

 

Publikationer rss feed

2018
 

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, Inge ; Vesth, Tammi Camilla ; Frisvad, Jens Christian ; Rasmussen, Jane Lind Nybo ; Theobald, Sebastian ; Kuo, Alan ; Bowyer, Paul ; Matsuda, Yudai ; Mondo, Stephen ; Lyhne, Ellen Kirstine ; Kogle, Martin Engelhard ; Clum, Alicia ; Lipzen, Anna ; Salamov, Asaf ; Ngan, Chew Yee ; Daum, Chris ; Chiniquy, Jennifer ; Barry, Kerrie ; LaButti, Kurt ; Haridas, Sajeet ; Simmons, Blake A. ; Magnuson, Jon K. ; Mortensen, Uffe Hasbro ; Larsen, Thomas Ostenfeld ; Grigoriev, Igor V. ; Baker, Scott E. ; Andersen, Mikael Rørdam
in: Proceedings of the National Academy of Sciences of the United States of America (ISSN: 0027-8424), vol: 115, issue: 4, pages: E753-E761, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1073/pnas.1715954115

 

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms

Ainsworth, Stuart ; Petras, Daniel ; Engmark, Mikael ; Süssmuth, Roderich D. ; Whiteley, Gareth ; Albulescu, Laura-Oana ; Kazandjian, Taline D. ; Wagstaff, Simon C. ; Rowley, Paul ; Wüster, Wolfgang ; Dorrestein, Pieter C. ; Arias, Ana Silvia ; M. Gutierrez, Jose ; Harrison, Robert ; Casewell, Nicholas R. ; Calvete, Juan J.
in: Journal of Proteomics (ISSN: 1874-3919), vol: 172, pages: 173-189, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.jprot.2017.08.016

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Locked nucleic acid: modality, diversity, and drug discovery

Hagedorn, Peter H. ; Persson, Robert ; Funder, Erik D. ; Albæk, Nanna ; Diemer, Sanna L. ; Hansen, Dennis J. ; Møller, Marianne R ; Papargyri, Natalia ; Christiansen, Helle ; Hansen, Bo R. ; Hansen, Henrik F. ; Jensen, Mads A ; Koch, Troels
in: Drug Discovery Today (ISSN: 1359-6446), vol: 23, issue: 1, pages: 101-114, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.drudis.2017.09.018

 

Glycoengineering in CHO cells: Advances in systems biology

Tejwani, Vijay ; Andersen, Mikael Rørdam ; Nam, Jong Hyun ; Sharfstein, Susan T
in: Biotechnology Journal (ISSN: 1860-6768), 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018     |    DOI: http://dx.doi.org/10.1002/biot.201700234

 

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Pereira, Sara ; Kildegaard, Helene Faustrup ; Andersen, Mikael Rørdam
in: Biotechnology Journal (Online) (ISSN: 1860-7314), 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018     |    DOI: http://dx.doi.org/10.1002/biot.201700499

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Method for reducing ammonium and lactate production in cho cells

Ley, Daniel (Inventor) ; Andersen, Mikael Rørdam (Inventor) ; Kildegaard, Helene Faustrup (Inventor)
Patent no.: WO2017EP70682 , Date: 22-02-2018

Type: Patent

Status: Published     |    Year: 2018

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Pros and cons of different therapeutic antibody formats for recombinant antivenom development

Laustsen, Andreas Hougaard ; Gutiérrez, José María ; Knudsen, Cecilie ; Johansen, Kristoffer H. ; Bermúdez-Méndez, Erick ; Cerni, Felipe A. ; Jürgensen, Jonas A. ; Ledsgaard, Line ; Martos Esteban, Andrea ; Øhlenschlæger, Mia ; Pus, Urska ; Andersen, Mikael Rørdam ; Lomonte, Bruno ; Engmark, Mikael ; Pucca, Manuela B.
in: Toxicon (ISSN: 0041-0101), vol: 146, pages: 151-175, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.toxicon.2018.03.004

 

Toxin-centric development approach for next-generation antivenoms

Laustsen, Andreas Hougaard
in: Toxicon (ISSN: 0041-0101), vol: 150, pages: 195-197, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.toxicon.2018.05.021

 

An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Singh, Ankita ; Kildegaard, Helene Faustrup ; Andersen, Mikael Rørdam
in: Biotechnology Journal (ISSN: 1860-6768), 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018     |    DOI: http://dx.doi.org/10.1002/biot.201800070

2017
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Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

Beuchert Kallehauge, Thomas ; Li, Shangzhong ; Pedersen, Lasse Ebdrup ; Kwang Ha, Tae ; Ley, Daniel ; Andersen, Mikael Rørdam ; Kildegaard, Helene Faustrup ; Min Lee, Gyun ; Lewis, Nathan E.
in: Scientific Reports (ISSN: 2045-2322), vol: 7, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1038/srep40388

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Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca

Lauridsen, Line P. ; Laustsen, Andreas Hougaard ; Lomonte, Bruno ; Gutiérrez, José María
in: Journal of Proteomics (ISSN: 1874-3919), vol: 150, pages: 98-108, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.jprot.2016.08.024

 

Fed-batch CHO cell culture for lab-scale antibody production

Fan, Yuzhou ; Ley, Daniel ; Andersen, Mikael Rørdam
part of: Recombinant Glycoprotein Production, pages: 147-161, 2017,

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1007/978-1-4939-7312-5_12

 

Engineer medium and feed for modulating N-glycosylation of recombinant protein production in CHO cell culture

Fan, Yuzhou ; Kildegaard, Helene Faustrup ; Andersen, Mikael Rørdam
part of: Heterologous Protein Production in CHO cells, pages: 209-226, 2016, Springer,

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1007/978-1-4939-6972-2_14

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Pitfalls to avoid when using phage display for snake toxins

Laustsen, Andreas Hougaard ; Lauridsen, Line P. ; Lomonte, Bruno ; Andersen, Mikael Rørdam ; Lohse, Brian
in: Toxicon (ISSN: 0041-0101), pages: 79–89, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.toxicon.2016.12.010

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Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus

Laustsen, Andreas Hougaard ; Engmark, Mikael ; Clouser, Christopher ; Timberlake, Sonia ; Vigneault, Francois ; Gutiérrez, José María ; Lomonte, Bruno
in: PeerJ (ISSN: 2167-8359), vol: 5, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.7717/peerj.2924

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Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

Laustsen, Andreas Hougaard ; Johansen, Kristoffer H. ; Engmark, Mikael ; Andersen, Mikael Rørdam
in: P L o S Neglected Tropical Diseases (Online) (ISSN: 1935-2735), vol: 11, issue: 2, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1371/journal.pntd.0005361

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Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data

Lund, Anne Mathilde ; Kaas, Christian Schrøder ; Brandl, Julian ; Pedersen, Lasse Ebdrup ; Kildegaard, Helene Faustrup ; Kristensen, Claus ; Andersen, Mikael Rørdam
in: B M C Systems Biology (ISSN: 1752-0509), vol: 11, issue: 1, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1186/s12918-017-0414-4

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Cell Factory Engineering

Davy, Anne Mathilde ; Kildegaard, Helene Faustrup ; Andersen, Mikael Rørdam
in: Cell Systems (ISSN: 2405-4712), vol: 4, issue: 3, pages: 262-275, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.cels.2017.02.010

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Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

de Vries, Ronald P. ; Riley, Robert ; Wiebenga, Ad ; Aguilar-Osorio, Guillermo ; Amillis, Sotiris ; Uchima, Cristiane Akemi ; Anderluh, Gregor ; Asadollahi, Mojtaba ; Askin, Marion ; Barry, Kerrie ; Battaglia, Evy ; Bayram, Özgür ; Benocci, Tiziano ; Braus-Stromeyer, Susanna A. ; Caldana, Camila ; Cánovas, David ; Cerqueira, Gustavo C. ; Chen, Fusheng ; Chen, Wanping ; Choi, Cindy ; Clum, Alicia ; dos Santos, Renato Augusto Corrêa ; de Lima Damásio, André Ricardo ; Diallinas, George ; Emri, Tamás ; Fekete, Erzsébet ; Flipphi, Michel ; Freyberg, Susanne ; Gallo, Antonia ; Gournas, Christos ; Habgood, Rob ; Hainaut, Matthieu ; Harispe, María Laura ; Henrissat, Bernard ; Hildén, Kristiina S. ; Hope, Ryan ; Hossain, Abeer ; Karabika, Eugenia ; Karaffa, Levente ; Karányi, Zsolt ; Kraševec, Nada ; Kuo, Alan ; Kusch, Harald ; LaButti, Kurt ; Lagendijk, Ellen L. ; Lapidus, Alla ; Levasseur, Anthony ; Lindquist, Erika ; Lipzen, Anna ; Logrieco, Antonio F. ; MacCabe, Andrew ; Mäkelä, Miia R. ; Malavazi, Iran ; Melin, Petter ; Meyer, Vera ; Mielnichuk, Natalia ; Miskei, Márton ; Molnár, Ákos P. ; Mulé, Giuseppina ; Ngan, Chew Yee ; Orejas, Margarita ; Orosz, Erzsébet ; Ouedraogo, Jean Paul ; Overkamp, Karin M. ; Park, Hee Soo ; Perrone, Giancarlo ; Piumi, Francois ; Punt, Peter J. ; Ram, Arthur F. J. ; Ramón, Ana ; Rauscher, Stefan ; Record, Eric ; Riaño-Pachón, Diego Mauricio ; Robert, Vincent A.R.G. ; Röhrig, Julian ; Ruller, Roberto ; Salamov, Asaf ; Salih, Nadhira S. ; Samson, Rob A. ; Sándor, Erzsébet ; Sanguinetti, Manuel ; Schütze, Tabea ; Sepčić, Kristina ; Shelest, Ekaterina ; Sherlock, Gavin ; Sophianopoulou, Vicky ; Squina, Fabio M. ; Sun, Jian-Hui ; Susca, Antonia ; Todd, Richard B. ; Tsang, Adrian ; Unkles, Shiela E. ; van de Wiele, Nathalie ; van Rossen-Uffink, Diana ; de Castro Oliveira, Juliana Velasco ; Vesth, Tammi Camilla ; Visser, Jaap ; Yu, Jae-Hyuk ; Zhou, Miaomiao ; Andersen, Mikael Rørdam ; Archer, David B. ; Baker, Scott E. ; Benoit, Isabelle ; Brakhage, Axel A. ; Braus, Gerhard H. ; Fischer, Reinhard ; Frisvad, Jens Christian ; Goldman, Gustavo H. ; Houbraken, Jos ; Oakley, Berl R. ; Pócsi, István ; Scazzocchio, Claudio ; Seiboth, Bernhard ; vanKuyk, Patricia A. ; Wortman, Jennifer Russo ; Dyer, Paul S. ; Grigoriev, Igor V.
in: Genome Biology (Online Edition) (ISSN: 1474-7596), vol: 18, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1186/s13059-017-1151-0

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Structure-based discovery of novel US28 small molecule ligands with different modes of action

Lückmann, Michael ; Amarandi, Roxana-Maria ; Papargyri, Natalia ; Høy Jakobsen, Mette ; Christiansen, Elisabeth ; Jensen, Lars Juhl ; Pui, Aurel ; Schwartz, Thue W. ; Rosenkilde, Mette M. ; Frimurer, Thomas M.
in: Chemical Biology & Drug Design (ISSN: 1747-0277), vol: 89, issue: 3, pages: 289-296, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1111/cbdd.12848

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Model-based analysis of N-glycosylation in Chinese hamster ovary cells

Krambeck, Frederick J. ; Bennun, Sandra V ; Andersen, Mikael Rørdam ; Betenbaugh, Michael J. ; Lisacek, Frederique (Editor)
in: P L o S One (ISSN: 1932-6203), vol: 12, issue: 5, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1371/journal.pone.0175376

 

Development of a Bacterial Biosensor for Rapid Screening of Yeast p-Coumaric Acid Production

Siedler, Solvej ; Khatri, Narendar K. ; Zsohar, Andrea ; Kjærbølling, Inge ; Vogt, Michael ; Hammar, Petter ; Nielsen, Christian Førgaard ; Marienhagen, Jan ; Sommer, Morten Otto Alexander ; Joensson, Haakan N.
in: A C S Synthetic Biology (ISSN: 2161-5063), vol: 6, issue: 10, pages: 1860-1869, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1021/acssynbio.7b00009

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Guiding recombinant antivenom development by omics technologies

Laustsen, Andreas Hougaard
in: New Biotechnology (ISSN: 1871-6784), 2017

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.nbt.2017.05.005

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Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping

Engmark, Mikael ; Lomonte, Bruno ; Gutiérrez, José María ; Laustsen, Andreas Hougaard ; De Masi, Federico ; Andersen, Mikael Rørdam ; Lund, Ole
in: P L o S Neglected Tropical Diseases (Print) (ISSN: 1935-2727), vol: 11, issue: 7, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1371/journal.pntd.0005768