Group publications

 

Publikationer rss feed

2018
 

Localization and characterization of CYP76AE2 part of thapsigargin biosynthesis in Thapsia garganica

Andersen, Trine Bundgaard ; Martinez-Swatson, Karen Agatha ; Rasmussen, Silas Anselm ; Boughton, Berin Alain ; Jørgensen, Kirsten ; Andersen-Ranberg, Johan ; Nyberg, Nils ; Christensen, Søren Brøgger ; Simonsen, Henrik Toft
in: Plant Physiology (ISSN: 0032-0889), vol: 176, issue: 1, 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018

 

Evaluation of synthetic promoters in Physcomitrella patens

Peramuna, Anantha Vithakshana ; Bae, Hansol ; Rasmussen, Erling ; Dueholm, Bjørn ; Waibel, Thomas ; Critchley, Joanna H. ; Brzezek, Kerstin ; Roberts, Michael ; Simonsen, Henrik Toft
in: Biochemical and Biophysical Research Communications (ISSN: 0006-291X), 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.bbrc.2018.04.092

2017
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Localization and in-vivo characterization of thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

Andersen, Trine Bundgaard ; Martinez-Swatson, Karen Agatha ; Rasmussen, Silas Anselm ; Boughton, Berin Alain ; Jørgensen, Kirsten ; Andersen-Ranberg, Johan ; Nyberg, Nils ; Christensen, Søren Brøgger ; Simonsen, Henrik Toft
in: Plant Physiology (ISSN: 0032-0889), vol: 174, issue: 1, pages: 56-72, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1104/pp.16.00055

 

Anthelmintic effects of forage chicory (Cichorium intybus) against free-living and parasitic stages of Cooperia oncophora

Pena-Espinoza, Miguel Angel ; Williams, Andrew R. ; Thamsborg, Stig M. ; Simonsen, Henrik Toft ; Enemark, Heidi L.
in: Veterinary Parasitology (ISSN: 0304-4017), vol: 243, pages: 204-207, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.vetpar.2017.07.008

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Stable production of the antimalarial drug artemisinin in the moss Physcomitrella patens

Binti Khairul Ikram, Nur Kusaira ; Kashkooli, Arman Beyraghdar ; Peramuna, Anantha Vithakshana ; van der Krol, Alexander R. ; Bouwmeester, Harro ; Simonsen, Henrik Toft
in: Frontiers in Bioengineering and Biotechnology (ISSN: 2296-4185), vol: 5, issue: 47, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.3389/fbioe.2017.00047

 

Effects of gamma irradiation and comparison of different extraction methods on sesquiterpene lactone yields from the medicinal plant Thapsia garganica L. (Apiaceae)

Mohamed Ibrahim, Abir M. ; Martinez-Swatson, Karen A. ; Benkaci-Ali, Farid ; Cozzi, Federico ; Zoulikha, Ferhat ; Simonsen, Henrik Toft
in: Journal of Applied Research on Medicinal and Aromatic Plants (ISSN: 2214-7861), vol: 8, pages: 26-32, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.jarmap.2017.09.002

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A Review of Biotechnological Artemisinin Production in Plants

Ikram, Nur K. B. K. ; Simonsen, Henrik Toft
in: Frontiers in Plant Science (ISSN: 1664-462X), vol: 8, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.3389/fpls.2017.01966

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Fragrant plants used as air fresheners in private households

Simonsen, Henrik Toft
part of: Book of Abstracts, Sustain 2017, 2017, Technical University of Denmark (DTU),
Presented at:
Sustain 2017, 2017, Kgs. Lyngby

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2017

2016
 

Anthelmintic activity of chicory (Cichorium intybus): in vitro effects on swine nematodes and relationship to sesquiterpene lactone composition

Williams, Andrew ; Pena-Espinoza, Miguel Angel ; Boas, Ulrik ; Simonsen, Henrik Toft ; Enemark, Heidi ; Thamsborg, Stig M.
in: Parasitology (Cambridge) (ISSN: 0031-1820), vol: 143, issue: 6, pages: 770-777, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1017/S0031182016000287

 

Evolution of NADPH-cytochrome P450 oxidoreductases (POR) in Apiales - POR 1 is missing

Andersen, Trine Bundgaard ; Hansen, Niels Bjørn ; Laursen, Tomas ; Weitzel, Corinna ; Simonsen, Henrik Toft
in: Molecular Phylogenetics and Evolution (ISSN: 1055-7903), vol: 98, pages: 21-28, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1016/j.ympev.2016.01.013

 

Meet the Moss - User Testing Our First Fragrance

Simonsen, Henrik Toft (Other)

Type: Sound/Visual production (digital)

Status: Published     |    Year: 2016

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The decision to germinate is regulated by divergent molecular networks in spores and seeds

Vesty, Eleanor F. ; Saidi, Younousse ; Moody, Laura A. ; Holloway, Daniel ; Whitbread, Amy ; Needs, Sarah ; Choudhary, Anushree ; Burns, Bethany ; Mcleod, Daniel ; Bradshaw, Susan J. ; Bae, Hansol ; King, Brian Christopher ; Bassel, George W. ; Simonsen, Henrik Toft ; Coates, Juliet C.
in: New Phytologist (ISSN: 0028-646X), vol: 211, issue: 3, pages: 952-966, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1111/nph.14018

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In vivo assembly of DNA-fragments in the moss, Physcomitrella patens

King, Brian Christopher ; Vavitsas, Konstantinos ; Ikram, Nur Kusaira Binti Khairul ; Schroder, Josephine ; Scharff, Lars B. ; Hamberger, Bjorn ; Jensen, Poul Erik ; Simonsen, Henrik Toft
in: Scientific Reports (ISSN: 2045-2322), vol: 6, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1038/srep25030

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Evolutionary prediction of medicinal properties in the genus Euphorbia L.

Ernst, Madeleine ; Saslis Lagoudakis, Haris ; Grace, Olwen M. ; Nilsson, Niclas ; Simonsen, Henrik Toft ; Horn, James W. ; Rønsted, Nina
in: Scientific Reports (ISSN: 2045-2322), vol: 6, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1038/srep30531

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Two key polymorphisms in a newly discovered allele of the Vitis vinifera TPS24 gene are responsible for the production of the rotundone precursor α-guaiene

Drew, D. P. ; Andersen, T. B. ; Sweetman, C. ; Møller, B. L. ; Ford, C. ; Simonsen, Henrik Toft
in: Journal of Experimental Botany (ISSN: 0022-0957), vol: 67, issue: 3, pages: 799-808, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1093/jxb/erv491

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Insight into Biochemical Characterization of Plant Sesquiterpene Synthases

Manczak, Tom ; Simonsen, Henrik Toft
in: Analytical Chemistry Insights (ISSN: 1177-3901), vol: 11, issue: S1, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.4137/ACI.S40292

 

Bryophytes - an emerging source for herbal remedies and chemical production

Sabovljevic, Marko S. ; Sabovljević, Aneta D. ; Ikram, Nur Kusaira K. ; Peramuna, Anantha Vithakshana ; Bae, Hansol ; Simonsen, Henrik Toft
in: Plant Genetic Resources (ISSN: 1479-2621), vol: 14, issue: 4, pages: 314-327, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1017/S1479262116000320

 

Role of the Colletotrichum acutatum sesquiterpene synthase CaTPS in the biosynthesis of sesquiterpenoids

Amby, Daniel Buchvaldt ; Manczak, Tom ; Petersen, Mikael Agerlin ; Sundelin, Thomas ; Weitzel, Corinna ; Grajewski, Maciej ; Simonsen, Henrik Toft ; Jensen, Birgit
in: Microbiology (ISSN: 1350-0872), vol: 162, pages: 1773–1783, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1099/mic.0.000361

 

Molecular phylogenetics as a predictive tool in plant-based drug discovery in the genus Euphorbia L.

Ernst, M. ; Saslis-Lagoudakis, C.H. ; Grace, O.M. ; Nilsson, N. ; Simonsen, Henrik Toft ; Horn, J.W. ; Stærk, D. ; Rønsted, N
in: Planta Medica (ISSN: 0032-0943), vol: 82, issue: S 01, 2016
Presented at:
9th Joint Meeting of AFERP, ASP, GA, JSP, PSE & SIF, 2016, Copenhagen

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1055/s-0036-1596164

 

Increasing Oil Bodies in Physcomitrella patens by Overexpressing Oil Body- Associated Proteins

Bae, Hansol ; Peramuna, Anantha Vithakshana ; Simonsen, Henrik Toft
Presented at:
Sustain-ATV Conference 2016, 2016, Kgs. Lyngby

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2016

 

Domesticating deadly carrots: Predicting the biosynthetic pathway of thapsigargins for the treatment of solid tumors

Martinez, K ; Simonsen, Henrik Toft ; Rønsted, N. ; Bundgaard Andersen, T. ; Barnes, C. ; Boughton, B. ; Cozzi, F.
in: Planta Medica (ISSN: 0032-0943), vol: 81, issue: S 01, 2016
Presented at:
9th Joint Meeting of AFERP, ASP, GA, JSP, PSE & SIF, 2016, Copenhagen

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1055/s-0036-1596793

2015
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Evolution of substrate recognition sites (SRSs) in cytochromes P450 from Apiaceae exemplified by the CYP71AJ subfamily

Dueholm, Bjørn ; Krieger, Celia ; Drew, Damian ; Olry, Alexandre ; Kamo, Tsunashi ; Taboureau, Olivier ; Weitzel, Corinna ; Bourgaud, Frederic ; Hehn, Alain ; Simonsen, Henrik Toft
in: B M C Evolutionary Biology (ISSN: 1471-2148), vol: 15, issue: 122, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1186/s12862-015-0396-z

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Sesquiterpene lactone containing extracts from two cultivars of forage chicory (Cichorium intybus) show distinctive chemical profiles and in vitro activity against Ostertagia ostertagi

Pena-Espinoza, Miguel Angel ; Boas, Ulrik ; Williams, Andrew ; Thamsborg, Stig M. ; Simonsen, Henrik Toft ; Enemark, Heidi
in: International Journal for Parasitology: Drugs and Drug Resistance (ISSN: 2211-3207), vol: 5, issue: 3, pages: 191-200, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1016/j.ijpddr.2015.10.002

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Thapsigargin-From Thapsia L. to Mipsagargin

Andersen, Trine Bundgaard ; Lopez, Carmen Quinonero ; Manczak, Tom ; Martinez, Karen ; Simonsen, Henrik Toft
in: Molecules (ISSN: 1420-3049), vol: 20, issue: 4, pages: 6113-6127, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.3390/molecules20046113

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Optimization of Biochemical Screening Methods for Volatile and Unstable Sesquiterpenoids Using HS-SPME-GC-MS

Andersen, Trine ; Cozzi, Federico ; Simonsen, Henrik Toft
in: Chromatography (ISSN: 1342-8284), vol: 2, issue: 2, pages: 277-292, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.3390/chromatography2020277