Postdoctoral Researchers in Protease Degradomics

DTU Bioengineering
onsdag 10 maj 17

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Frist 4. juni 2017
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The section of Protein Science and Signalling Biology at the Department of Biotechnology and Biomedicine has openings for two positions as postdoctoral researchers. The positions will be available from September 2017 or soon thereafter.

Successful applicants will work within the newly established research group ‘Protease Degradomics’ headed by Professor Ulrich auf dem Keller and funded by a Novo Nordisk Foundation (NNF) Young Investigator Award.

In our research group, we apply and develop advanced positional proteomics workflows to identify proteases, elucidate their interactions and determine their substrates in inflammation, repair and regeneration. With a major focus on the skin, we aim at elucidating interdependent proteolytic pathways and their disturbance in disease to provide a basis for the development of novel strategies for diagnostics and therapeutic intervention.

Responsibilities and tasks
Within the NNF funded research program, each newly recruited postdoctoral researcher will lead one of the two lines of research:

1. Functional mapping of protease networks in normal and inflamed skin

This project will employ advanced positional proteomics to identify and characterize interconnected protease activities using in vitro assays, skin cell culture systems (2D and 3D) and genetically modified mouse models

2. Global characterization of aberrant protease activities in healing impairments

In this project, we will identify and characterize proteolytic signatures as markers of wound progression by degradomics analyses of clinical wound exudates from patients with normal and impaired healing.

Qualifications
Applicants should hold a PhD in a life sciences discipline, have excellent communication skills and be extensively trained in protein biochemistry, cell culture systems, biological sample preparation and computational data analysis. Prior experience in mass spectrometry-based proteomics is not mandatory but would be highly advantageous, and knowledge of targeted proteomics workflows would be a strong asset. The ideal candidates would be also familiar with handling mice.

We offer
We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.

Salary and terms of employment
The appointment will be based on the collective agreement with the Confederation of Professional Associations. The allowance will be agreed with the relevant union.

The positions will be located at the DTU Lyngby campus in a newly established research building hosting ultra-modern laboratories for protein science and the DTU Proteomics Core with state-of-the-art mass spectrometers. Maximum period of employment is 4 years.

Further Information
Additional information may be obtained from Dr. Ulrich auf dem Keller: ulrich.aufdemkeller@biol.ethz.ch

Application procedure
Please submit your online application no later than 4 June 2017.

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill in the online application form, and attach all your materials in English in one PDF file. The file must include:
  • Application (cover letter)
  • CV
  • Diploma (MSc/PhD)
  • List of publications
Applications and enclosures received after the deadline will not be considered.
All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) conducts research, educates future bio-engineers, provides scientific advice and innovate within the areas of microbiology, biochemistry, biotechnology and biomedicine. The research at DTU Bioengineering is at the highest international level and focuses on the societal and scientific challenges within the field. Research is conducted within three main areas: Microbial ecology and physiology, Industrial biotechnology and cell factories, and Biomedicine and health. The department has extensive collaboration with national and international research units and industries. DTU Bioengineering has approx. 150 employees, of which 2/3 is scientific staff. The department is located at DTU Lyngby Campus.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,300 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.