On 1 April 2019, Alexander Kai Büll was appointed professor at DTU Bioengineering.
This is celebrated with an inaugural lecture by Alexander Kai Büll titled:
Biomolecular self-assembly - from disease mechanisms to biomaterials
The lecture is followed by a reception. Registration is not necessary.
Abstract:
Biomolecular self-assembly - from disease mechanisms to biomaterials
The self-assembly of biomolecules, in particular proteins, into ordered structures is a fascinating process that plays important roles in both biological function and disease. In this inaugural lecture I will highlight some of the contributions I have made to an increased understanding of the mechanisms of amyloid fibril formation, a process most notably linked to neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. I will also discuss how such mechanistic information can be used to characterize the mode of action of potential inhibitors of these processes.
Amyloid fibrils are not only formed by disease-related proteins, but also by proteins without any link to human disease, and which can be obtained in large quantities. I will present some studies that aim to exploit the self-assembly of such proteins, as well as synthetic peptides for the creation of biomaterials.