Mammalian Cell Line Engineering

Red antibodies on pink background

Research Group

Mammalian Cell Line Engineering

Our research is addressing the need to rapidly design and engineer mammalian cell lines that produce high quality biopharmaceuticals at high yields.

Mammalian cells, especially Chinese hamster ovary (CHO) cells, are the most commonly used host cell for production of large and complex therapeutic proteins, known as biopharmaceuticals. This is due to their ability to express and secrete these complex proteins with post-translational modifications similar to those produced in humans. The process going from drug discovery to manufacturing is complicated and time-consuming, making the final product very expensive and limits the rate at which new biopharmaceuticals can be produced for proof-of-concept trials.

We aim to:

1. Develop methods that support rapid cell line development from discovery of new biopharmaceuticals to production, decreasing the cost of development and production, and broaden the availability and range of biopharmaceuticals on the market.

2. Rationally engineer mammalian cells by gene target identification to increase biopharmaceutical product quantity and product quality, especially for more difficult-to-express proteins.