Postdoc in Brain Organoid Culture for 3D Brain-on-a-Chip Systems

torsdag 07 jul 22

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Frist 22. august 2022
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If you are establishing your career as scientist and you are looking for the best possible foundation for fulfilling your dreams and ambitions, it is right here in front of you. In the Bioanalytics group at DTU Bioengineering, you will conduct research in the forefront of neurotech development as part of a multidisciplinary team of researcher within the European Pathfinder Open project “OpenMIND - Opto-Electronic Neural Connectoid Model Implemented for Neurodegenerative Diseases”. Our overall aim in OpenMIND is to develop a novel 3D brain-on-a-chip concept for modelling Parkinson´s disease and other neurodegenerative disorders. The technology is based on interconnected brain organoids (so called connectoids) from different brain regions equipped with internalized 3D micro-biosensors- and waveguides for neurotransmitter sensing and control. This postdoc position will be a great opportunity for you to conduct groundbreaking research and supervise students in close collaboration with other researchers within the group and international partners with the opportunity for international research stays and visits.

Responsibilities and qualifications
Your role will be to lead the work on developing 3D brain organoids (optogenetically modified) from different brain regions using human pluripotent stem cells (hPSCs). Furthermore, to develop means to connect these brain organoids into connectoid networks to mimic the dopaminergic circuitry of the brain involved in Parkinson´s disease. Together with other researchers in the group and the OpenMIND project you will take part in interfacing the connectoid network with 3D micro-electrodes and waveguides to enable neurotransmitter sensing and control within the connectoid network.

Your primary responsibility will be:

  • Establishing 3D brain organoid cultures from hPSCs and their characterization
  • Development and rheological characterization of gels for optimized culturing of different cell- and organoid types
  • Fast prototyping of brain-on-chip systems that enable brain organoid/connectoid culture.
  • Formation of interconnected organoid networks (connectoids)
  • Investigating functionality of formed connectoids
  • Supervision of MSc and PhD students in the group related to the research area
  • Participation in preparation of the periodical EU reports and in the projects meetings as well as general scientific dissemination of the conducted research

You need to have the following qualifications: 

  • A background in cell biology, brain organoid culture and hydrogels
  • Preferably with some basic experience with prototyping techniques such as casting, molding, and/or 3D bioprinting.
  • Flexibility and ability to work in a multi-disciplinary research team.
  • Fluent in spoken and written English.
  • Excellent writing, presentation, and communication skills. 

As a formal qualification, you must hold a PhD degree (or equivalent). 

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation, and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 2 years with starting date 1 November 2022. 

You can read more about career paths at DTU here.

Further information
For inquiries contact Jenny Emnéus tel: +45 2547 3548 or Arto Heiskanen tel: +46 734436917 in the Bioanalytics group.

You can read more about DTU Bioengineering on www.bioengineering.dtu.dk

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Your complete online application must be submitted no later than 22 August 2022 (Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Application (cover letter)
  • CV
  • Academic Diplomas (MSc/PhD – in English)
  • List of publications 
  • Two letters of recommendation 

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion, or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science industry and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.