Postdoc in Advanced Antibody Discovery Technologies

torsdag 16 sep 21

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Frist 30. oktober 2021
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We are looking for a postdoctoral researcher within the field of advanced antibody discovery technologies from the 1st of January 2022 (or soon thereafter) for a 4-year position. The candidate will be part of an extraordinarily ambitious antibody development project with the aim of developing a fully recombinant antivenom against snakebite for sub-Saharan Africa.

The Tropical Pharmacology Lab
Snakebite envenoming is a Neglected Tropical Disease that each year claims 150,000 lives and maims another 400,000 victims for life. Existing treatments based on polyclonal antibodies derived from the blood of immunized animals are scarce and have a number of drawbacks, including high cost a propensity to elicit adverse reactions due to their immunogenic disposition. Scientific and technological advancement is highly warranted and may enable the introduction of improved therapies for snakebite victims living in impoverished rural areas worldwide!

In the Tropical Pharmacology Lab, we are championing the development of recombinant antivenoms based on mixtures of carefully selected human monoclonal antibodies with the purpose of bringing efficacious, safe, and affordable next-generation snakebite therapeutics to life. To pursue this goal, we utilize advanced antibody discovery technologies for designing antibodies with special binding properties, such as being broadly-neutralizing, being directed to distinct anatomic sites, and/or being possible to administer at exceptionally low dose.

The research group is headed by Associate Professor Andreas Hougaard Laustsen and is based in the section for Protein Science & Biotherapeutics at the Department of Biotechnology and Biomedicine at the Technical University of Denmark.

Responsibilities and qualifications
The project is funded by Wellcome and has the aim of delivering tangible human health impact via the development of novel snakebite therapeutics. The candidate will be responsible of conducting discovery campaigns using phage display selection against snake toxins from different protein families to find cross-reactive scFvs. The candidate will assess the binding properties of these scFvs after expression and purification and convert these into IgGs.

The candidate will be part of a team of 1 senior scientist, 3 other postdoctoral scientists, and 2 laboratory technicians working on toxin biochemistry, antibody and nanobody discovery, and biophysical characterization of antibodies with the purpose of developing a recombinant oligoclonal antibody cocktail that can neutralize the venoms of the medically most important snakes of sub-Saharan Africa. The project will thus be highly collaborative.

The position may potentially involve co-supervision of PhD and M.Sc. students within the research topic, but is not expected to involve any significant teaching responsibilities.

Applicants should hold a PhD in a relevant life sciences discipline, have excellent communication skills, and be extensively trained in antibody discovery, molecular biology, and protein engineering. In our research group, we highly value collaboration, and it will be expected that the candidates can demonstrate that he/she has a track record for successfully collaborating with his/her peers and students.

It is expected that the applicant has significant experience with one or more of the following techniques:

  • Phage display technology
  • Phage library construction
  • ELISA, Time-Resolved Fluorescence Assay, DELFIA, SPR
  • Assay development
  • Molecular biology (e.g. cloning, PCR, sequencing etc.)
  • Recombinant protein expression and purification in bacteria, yeast and/or mammalian cells
  • RP-HPLC and/or ÄKTA

Assessment
In the assessment of the candidates, consideration will be given to:

  • Experience with antibody discovery
  • Experience with molecular and/or synthetic biology
  • International impact and experience
  • Leadership potential and collaboration
  • Communication skills

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

More specifically in the Tropical Pharmacology Lab, we are a group of high performing scientists that share the vision that science is supposed to benefit humankind, especially underprivileged societies and/or societal groups. This shared vision with a very international outreach has created an academic environment that is ambitious and innovative fueled by an exceptionally collegially supportive attitude to both people and their work. We welcome people with all types of backgrounds and strive for diversity. Our research group is highly active in numerous outreach activities and our international travel agendas are typically busy. Finally, group members typically have an entrepreneurial attitude, resulting in the establishment of a number of spin-out biotech companies by group members.

See more: www.tropicalpharmacology.com

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

If you are a non-Dane (or have lived for a sufficient number of years outside of Denmark), you may be eligible for the attractive Researcher Tax scheme: https://skat.dk/skat.aspx?oid=97319. Successful application to this scheme is, however, not promised by DTU.

You can read more about career paths at DTU here.

The positions will be located at the DTU Lyngby campus in a newly established research building hosting ultra-modern laboratories for antibody discovery and phage display technology with neighboring laboratories with state-of-the-art facilities for protein science and proteomics. 

Further Information
Additional information may be obtained from Assoc. Prof. Andreas Hougard Laustsen, ahola@bio.dtu.dk

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Please submit your online application no later than 30 October 2021.

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one PDF fileThe file must include:

  • Application (cover letter)
  • CV
  • List of publications
  • H-index, and ORCID (see e.g. http://orcid.org/)
  • Diploma (MSc/PhD)

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Bioengineering
The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science industry and point towards innovation, new businesses and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 210 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.