Instrumentation
Hardware
The DTU Proteomics Core is equipped with state-of-the-art instrumentation including Orbitrap™-based mass spectrometers and Nano-LC UHPLC systems. Additionally, the facility houses equipment for all stages of sample preparation.
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The Orbitrap Exploris 480 mass spectrometer enables highly sensitive and accurate protein identification in complex mixtures. It is well suited for in-depth global analyses using both DDA and DIA acquisition methods, and supports targeted quantification via PRM. The facility houses three of these instruments.
- The Orbitrap Eclipse Tribrid mass spectrometer enables highly sensitive and accurate protein identification in complex mixtures. It supports Electron Transfer Dissociation (ETD), allowing detailed analysis of labile post-translational modifications such as phosphorylation and glycosylation. The instrument is compatible with PRM for targeted quantification and is the platform of choice for TMT (tandem mass tag) experiments using MS3-based methods.
