Postdoc in Immunopeptidomics, Degradomics and Cancer Immunotherapy

Monday 27 Sep 21

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We have an opening for a postdoctoral researcher position within the fields of immunopeptidomics, degradomics and cancer immunotherapy with earliest start date of 1st of January 2022.

The successful applicant will work within the research group Protease Network Degradomics headed by Professor Ulrich auf dem Keller.

In our research group, we apply and develop advanced positional MS-based proteomics workflows to identify proteases, determine their substrates, elucidate their interactions and unravel their functions in health and disease with the aim to provide a basis for the development of novel strategies for diagnostics and therapeutic intervention.

The group is part of the Section for Protein Science and Biotherapeutics at DTU Bioengineering at Technical University of Denmark (DTU) with access to state-of-the-art facilities, including the DTU Proteomics Core with cutting-edge mass spectrometry equipment (currently two ThermoFisher Orbitrap Eclipse Tribrids, one Exploris 480 and two Q Exactive Classics).

Responsibilities and qualifications
The project is funded by the Danish Cancer Society and explores a novel mechanism of proteolytic control of MHC-I tumor antigen presentation. The successful applicant will determine the immunopeptidome of cancer cell lines engineered for activity of a tumor suppressor protease with roles in cell density control and tumor antigenicity. The applicability of this mechanism in cancer immunotherapy will be evaluated in collaboration with leading researchers in the field at DTU as well as clinical collaborators.

Applicants should hold a PhD in a life sciences discipline, have excellent communication skills and be extensively trained in protein biochemistry, cell culture systems, biological sample preparation and computational data analysis. Prior experience in MS-based proteomics and immunopeptidomics would be highly advantageous, and knowledge of targeted proteomics workflows would be a strong asset.

The successful candidate is expected to have significant experience with one or more of these technologies:

  • MS-based quantitative proteomics
  • Immunopeptidomics (sample preparation and MS analysis)
  • Mammalian cell culture
  • Cell line engineering (CRISPR, shRNA)
  • Immunohistochemistry

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Confederation of Professional Associations. The allowance will be agreed with the relevant union.

The position is fully funded for two years. Maximum employment time for postdocs at DTU is four years.

You can read more about career paths at DTU here.

Further Information
Additional information may be obtained from Prof. Ulrich auf dem Keller,

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Please submit your online application no later than 30 October 2021.

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Application (cover letter)
  • CV
  • Diploma (MSc/PhD)
  • List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Bioengineering
The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science industry and point towards innovation, new businesses and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 210 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.