The Biophysics core contains a series of instruments for the quantitative study of biomolecules.
QSense Pro (Biolin Scientific) quartz crystal microbalance (QCM) for the study of interactions between molecular species bound to a surface and in solution. Up to 8 flow cells can be operated in parallel.
Prometheus Panta (Nanotemper), a combined differential scanning fluorimetry (DSF), dynamic light scattering (DLS) and static light scattering (SLS) microcapillary (48 samples in parallel) based instrument. Can be used to quantify thermal and chemical stability of proteins and their aggregation.
FIDAone (FIDAbio) flow-induced dispersion analysis (FIDA) instrument for the quantification of biomolecular binding and interactions. Can also be used to quantify liquid-liquid phase separation and aggregation of proteins.
ProbeDrum instrument (Probation Labs), a cuvette-based instrument which can be used to measure fluorescence emission, UV-Vis spectra and light scattering intensity simultaneously on the same sample, while controlling temperature and pH. Also has a titrator for pH titrations or binding curves.
Drive Atomic force microscope (AFM, from Nanosurf) to perfom imaging in air and liquid and force spectroscopy for quantification of materials properties.
Full suite for the fabrication and operation of microfluidic devices (PDMS and Flexdym). Lithography in SU-8 and dry film. Inverted microscope (Zeiss), syringe pumps and pressure controllers (Elvesys) for operation of the devices.
Surface plasmon resonance (SPR, Biacore), biolayer interferometry (BLI), circular dichroism (CD) spectrometer and various isothermal titration calorimeters (ITC) and differential scanning calorimeters (DSC) available