Advanced Mammalian Cell Engineering
The group’s overall goal is to engineer mammalian cells for improved cellular behavior. Some areas of interest include:
Optimizing biologics production through data-driven improvements to host cell lines
The production of biotherapeutics (e.g., protein, gene, and cell therapies), remains a long and costly process. By generating high-dimensional omics data and using unbiased statistical approaches including AI/ML classifiers, we aim to identify targets that can be used for direct genetic engineering of host cells to predispose them towards higher production.
Next-generation cultured meat cell lines with improved metabolic efficiency
Cultured meat has the potential to significantly decrease the climate impact of meat consumption, however, this technology is currently not cost-competitive with traditional meat production. We aim to reshape cellular metabolism to reduce waste generation and simplify nutritional requirements.
Exploration of Warburg-null cell lines for biological understanding and biotherapeutic discovery
We have successfully eliminated the Warburg effect (a ubiquitous phenomenon where proliferative mammalian cells, such as tumors, produce lactate even in the presence of oxygen) in several mammalian cell lines without any apparent detriment on cell growth. We aim to characterize
- the cellular response to the elimination of this phenotype and
- whether these cell lines can inform the identification of novel oncology therapeutics.
We are highly interested in collaborations, both industrial and academic.
