Precision Medicine Technologies

At the Precision Medicine Technologies Lab, our mission is to create novel tools that accelerate the development of next-generation gene and cell therapies by making them more effective, safer, and affordable for patients with currently incurable diseases.

To achieve this, we combine expertise in CRISPR technologies, induced pluripotent stem cell (iPSC)-derived model systems, and the design of novel therapeutic strategies. Our work is built on two core pillars:

1. Safer and more precise genetic medicines
   Gene editing technologies such as CRISPR hold enormous potential, but their full impact depends on safety and specificity. We are developing synthetic regulatory elements that control how these therapies are expressed in the body. By fine-tuning when and where gene-editing tools are active, we aim to minimize unwanted effects and improve their overall safety profile.
2. Advanced model systems for therapy testing
   Effective treatments require reliable preclinical models. We are streamlining, optimizing and scaling high-throughput protocols to make the testing of gene and cell therapies more reproducible, rapid, and comprehensive. This includes the development of iPSC-derived systems that better capture the complexity of human biology and disease.

Our approach is highly integrative. We combine computational analyses of large-scale single-cell transcriptomic and proteomic datasets with innovative wet lab methods, such as pooled library designs and high-throughput screening. This synergy allows us to create powerful tools ranging from synthetic regulatory elements that finely tune gene expression to engineered proteins that selectively eliminate unwanted cells in model systems. The ultimate aim of our research is to empower the broader field of genetic medicine by providing the tools necessary to bring safer, more effective therapies to patients.

Moreover, we believe that science thrives on teamwork, and we are grateful to our collaborators in our local and international network across both academia and industry. Within the lab, we cultivate an interdisciplinary environment where computational biologists and experimental scientists work side by side, fostering creativity and innovation. 

We are also committed to training the next generation of researchers and actively support fellowship applications, including Marie Curie, EMBO, Lundbeck Foundation, Novo Nordisk Foundation, and others.